Discovery of novel PTP1B inhibitors with antihyperglycemic activity

Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors from Natural Products: Discovery of Next-Generation Antihyperglycemic Agents.

Diabetes mellitus is a chronic condition associated with the metabolic impairment of insulin actions, leading to the development of life-threatening complications. Although many kinds of oral antihyperglycemic agents with different therapeutic mechanisms have been marketed, their undesirable adverse effects, such as hypoglycemia, weight gain, and hepato-renal toxicity, have increased demand for...

Discovery of Novel Haloalkane Dehalogenase Inhibitors.

Haloalkane dehalogenases (HLDs) have recently been discovered in a number of bacteria, including symbionts and pathogens of both plants and humans. However, the biological roles of HLDs in these organisms are unclear. The development of efficient HLD inhibitors serving as molecular probes to explore their function would represent an important step toward a better understanding of these interest...

discovery of novel 1,3,4-thiadiazol-2-yl hydrazones of aromatic aldehydes as potent inhibitors of human platelet-aggregation with dual inhibitory activity

International Journal of Pharma and Bio Sciences NOVEL SMALL MOLECULE INHIBITORS OF PTP1B

Protein tyrosine phosphatase is a classical non receptor tyrosine phosphotase enzyme and is an important regulator in several signaling pathways including insulin and leptin. PTP1B is a negative regulator of insulin receptor (IR) which dephosphorylates tyrosine residues of Insulin Receptor tyrosine Kinase (IRK) domain and induces resistance to insulin sensitivity and obesity up on over expressi...

Development of novel protein tyrosine phosphatase - 1B (PTP1B) inhibitors to enhance insulin cell signaling

Diabetes mellitus is a primary cause for large number of pathophysiologic co-morbidities including obesity, hypertension, hyperlipidemia, atherosclerosis. Obesity is intimately associated with diabetes, which is not only a major but also a costly healthcare problem for the individual and to the society. The World Health Organization (WHO) estimates that approximately 135 million people worldwid...